Properties of statins

Variable	Atorvastatin	Fluvastatin	Lovastatin	Pravastatin	Rosuvastatin	Simvastatin
LDL cholesterol reductions (dose range, mg)	38-54 percent (10-80)	17-33 percent (20-80)	29-48 percent (20-80)	19-40 percent (10-40)	52-63 percent (10-40)	28-48 percent (10-80)
Elimination half-life, hours	15-30	0.5-2.3	2.9	1.3-2.8	19	2-3
Bioavailability, percent	12	19-29	5	18	20	5
Protein binding, percent	80-90	>99	>95	43-55	88	94-98
Solubility	Lipophilic	Lipophilic	Lipophilic	Hydrophilic	Hydrophilic	Lipophilic
Cytochrome 450 metabolism and lsozyme	3A4	2C9	3A4	-	Limited 2C9	3A4, 3A5
Active metabolites	Yes	No	Yes	No	No	Yes
Effect of food on absorption of drug	None	Negligible	Increased absorption	Decreased absorption	None	None
Optimal time of administration	Evening	Bedtime	With meals (morning and evening)	Bedtime	Anytime	Evening
Renal excretion of absorbed dose, percent	2	<6	10	20	10	13